Cytokeratin 18 (KRT18) Rabbit Polyclonal Antibody

CAT#: TA354929

Rabbit anti CK-18(Non-phospho) Polyclonal Antibody


USD 355.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide surrounding to the epitope -SAASVYA- without phosphorylation site at Serine 33 of Cytokeratin 18 protein from human origin. It is identical among human, mouse, rat, etc.
Formulation This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size ~48 kDa
Gene Name keratin 18
Background Keratin polypeptides 8 (basic keratin) and 18 (acidic keratin) exist in combination as K8/K18 which are the cytoskeletal intermediate filament proteins of hepatocytes while K8/K18/K19 are the keratins of hepatobiliary ductal cells. Hepatocyte K8/K18 are highly abundant and behave as stress proteins with injury-inducible expression. K8 and K18 are cytoprotective stress proteins that play a central role in guarding hepatocytes from apoptosis. Hepatocellular carcinoma have been reportedly defined by the use of antibodies that recognize only cytokeratins 8 and 18. K18 Ser33 as an interphase phosphorylation site, which increases its phosphorylation during mitosis in cultured cells and regenerating liver, and as an in vitro cdc2 kinase phosphorylation site.Phosphorylation of Ser33 and Ser52 are involved in keratin subcellular distribution.
Synonyms CYK18; K18
Reference Data
Protein Pathways Pathogenic Escherichia coli infection

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.