SAMHD1 Rabbit Polyclonal Antibody

CAT#: TA355001

Rabbit Polyclonal Anti-SAMHD1 (phospho Thr592) Antibody

Product Images

Western blot analysis of SAMHD1 (phospho Thr592) in 293 cells transfected with (A) empty expression vector, (B) wild-type SAMHD1, (C) SAMHD1 (T592A) and (D) SAMHD1 (T592E) with SAMHD1 (phospho Thr592) antibody at 1ug/ml.

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  Immunohistochemistry of SAMHD1 (phospho Thr592) in human brain tissue with SAMHD1 (phospho Thr592) antibody at 2.5ug/ml.

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  Immunofluorescence of phosphoSAMHD1 in human brain tissue with phosphoSAMHD1 antibody at 20ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: at 0.5-1µg/ml.IHC starting at 2.5µg/mL. IF start at 20µg/mL.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Phospho-SAMHD1 antibody was raised against a phosphorylated 18 amino acid peptide near the carboxy terminus of human Phospho-SAMHD1 surrounding T592.
• Formulation: SAMHD1 (phospho Thr592) antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SAMHD1 (phospho Thr592) antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 69 kDa
• Gene Name: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
• Database Link:
  NP_056289
  Entrez Gene 56045 MouseEntrez Gene 25939 Human
  UniProt ID Q9Y3Z3
• Background: The SAM domain and HD domain 1 (SAMHD1) protein is upregulated in response to viral infection and is thought to play a role in innate immunity (1). SAMHD1 blocks the infection of HIV-1 and SIVdeltaVpx before reverse transcription in macrophages and dendritic cells (2), and this restriction is regulated by phosphorylation of SAMHD1 (3). Mutations in this gene have been associated with Aicardi-Goutieres syndrome (1).
• Synonyms: AGS5; DCIP; HDDC1; Mg11; MOP-5; MOP5; SBBI88
• Note: SAMHD1 (phospho Thr592) antibody can be used for detection of SAMHD1 (phospho Thr592) by western blot at at 0.5 - 1 µg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.