SAMHD1 Rabbit Polyclonal Antibody

CAT#: TA355002

Rabbit Polyclonal Anti-SAMHD1 Antibody

Product Images

Western blot analysis of SAMHD1 in Daudi cell lysate with SAMHD1 antibody at 1ug/ml in (A) the absence and (B) the presence of blocking peptide.

• 

  Immunohistochemistry of SAMHD1 in human brain tissue with SAMHD1 antibody at 5ug/ml.

• 

  Immunofluorescence of SAMHD1 in Daudi cells with SAMHD1 antibody at 20ug/ml.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1-2µg/ml. IHC starting at 5µg/mL. IF start at 20µg/mL.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SAMHD1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human SAMHD1.
• Formulation: SAMHD1 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SAMHD1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 65, 69 kDa; Observed: 62 kDa
• Gene Name: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
• Database Link:
  NP_056289
  Entrez Gene 56045 MouseEntrez Gene 25939 Human
  UniProt ID Q9Y3Z3
• Background: The SAM domain and HD domain 1 (SAMHD1) protein is upregulated in response to viral infection and is thought to play a role in innate immunity (1). SAMHD1 blocks the infection of HIV-1 and SIVdeltaVpx before reverse transcription in macrophages and dendritic cells (2), and this restriction is regulated by phosphorylation of SAMHD1 (3). Mutations in this gene have been associated with Aicardi-Goutieres syndrome (1).
• Synonyms: AGS5; DCIP; HDDC1; Mg11; MOP-5; MOP5; SBBI88
• Note: SAMHD1 antibody can be used for detection of SAMHD1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.