DIS3L2 Rabbit Polyclonal Antibody

CAT#: TA355005

Rabbit Polyclonal Anti-DIS3L2 Antibody

Product Images

Western blot analysis of DIS3L2 in 3T3 cell lysate with DIS3L2 antibody at 1ug/ml.

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  Immunohistochemistry of DIS3L2 in rat brain tissue with DIS3L2 antibody at 5ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1-2µg/ml.IHC starting at 5µg/mL.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DIS3L2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human DIS3L2. The immunogen is located within amino acids 720 - 770 of DIS3L2.
• Formulation: DIS3L2 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: DIS3L2 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 97 kDa; Observed: 94 kDa
• Gene Name: DIS3 like 3'-5' exoribonuclease 2
• Database Link:
  NP_689596
  Entrez Gene 208718 MouseEntrez Gene 367307 RatEntrez Gene 129563 Human
  UniProt ID Q8IYB7
• Background: The exosome is involved in a multitude of cellular RNA processing and degradation events (1). DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species (2). DIS3L2 is a paralog of DIS3, but unlike DIS3 is located in the cytoplasm (3). DIS3L2 defines a novel eukaryotic RNA degradation pathway and preferentially targets uridylated RNA (4). DIS3L2 mutations have also been associated with sporadic Wilms tumors (3).
• Synonyms: FAM6A; FLJ36974; MGC42174; OTTHUMP00000203808
• Note: DIS3L2 antibody can be used for detection of DIS3L2 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.