CTLA4 Mouse Monoclonal Antibody [Clone ID: 8A1]

CAT#: TA355059

Mouse Monoclonal Anti-CTLA-4 Antibody [8A1]

USD 500.00

5 Days*

Size
    • 100 ug

Other products for "CTLA4"

Specifications

Product Data
Clone Name 8A1
Applications ELISA, IF, IHC, WB
Recommended Dilution WB: 1-2µg/mL.IHC starting at 5µg/Ml.IF start at 20µg/mL.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen CTLA-4 antibody was raised against the extracellular domain of human CTLA-4.
Formulation CTLA-4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification CTLA-4 Antibody is supplied as protein A purified IgG1.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size Predicted: 25 kDa; Observed: 32 kDa
Gene Name cytotoxic T-lymphocyte associated protein 4
Background The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), also known as CD152, is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells (1,2). Both it and the homologous T-cell co-stimulatory protein CD28 bind to CD80 (B7-H1) and CD86 (B7-H2) on antigen-presenting cells (APCs) (3). Mutations in the CTLA-4 gene have been implicated in multiple autoimmune diseases (4). CTLA-4 also functions as an immune checkpoint protein, and anti- CTLA-4 antibodies have been successfully used in the treatment of cancer (5).
Synonyms CD; CD28; CD152; CELIAC3; CTLA-4; GRD4; GSE; ICOS; IDDM12
Note CTLA-4 antibody can be used for detection of CTLA-4 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.