TIGIT Mouse Monoclonal Antibody [Clone ID: 10B1]

CAT#: TA355125

Mouse Monoclonal Anti-TIGIT Antibody [10B1]

USD 500.00

2 Weeks*

Size
    • 100 ug

Other products for "TIGIT"

Specifications

Product Data
Clone Name 10B1
Applications FC, IF, IHC
Recommended Dilution IHC start at 2 ug/mL. IF start at 1 ug/mL. FC start at 1 ug/mL. ICC start at 1 ug/mL.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen TIGIT antibody was raised against the extracellular domain of human TIGIT
Formulation TIGIT Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification TIGIT Antibody is supplied as protein A purified IgG1.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size Predicted: 26 kDa; Observed: 47 kDa
Gene Name T-cell immunoreceptor with Ig and ITIM domains
Background TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses .Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer.
Synonyms DKFZp667A205; FLJ39873; VSIG9; VSTM3; WUCAM
Reference Data
Protein Families Transmembrane

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.