Lymphocyte Activation Gene 3 (LAG3) Mouse Monoclonal Antibody [Clone ID: 1G4]

CAT#: TA355132

Mouse Monoclonal Anti-LAG3 Antibody [1G4]

USD 500.00

5 Days*

Size
    • 100 ug

Other products for "LAG3"

Specifications

Product Data
Clone Name 1G4
Applications ELISA, FC, IF, IHC, WB
Recommended Dilution ELISA start at 0.25 ug/mL. WB start at 0.25 ug/mL. ICC start at 1 ug/mL. IF start at 10 ug/mL. IHC start at 5 ug/mL. FC start at 1 ug/mL.
Reactivities Human
Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen LAG-3 antibody was raised against the extracellular domain of human LAG-3
Formulation LAG-3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification LAG-3 Antibody is supplied as protein A purified IgG1.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size Predicted: 55 kDa; Observed: 60, 70, 80 kDa
Gene Name lymphocyte activating 3
Background The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity, negatively regulating T-cell function and homeostasis.It is expressed in B, T, and NK cells, monocytes, and dendritic cells, and acts to regulate T cell expansion. LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy.
Synonyms CD223; FDC; LAG-3
Reference Data
Protein Families Transmembrane

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.