BCMA (TNFRSF17) Rabbit Monoclonal Antibody [Clone ID: DM4]
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Specifications
Product Data | |
Clone Name | DM4 |
Applications | FC, FN |
Recommended Dilution | Flow Cyt 1/100; MMTumor cell killing |
Reactivities | Human |
Host | Rabbit |
Isotype | scFv |
Clonality | Monoclonal |
Immunogen | Recombinant human BCMA (Met1-Ala54) (TP723924) produced by using human HEK293 cells |
Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. Preservative: 0.1% Procline 300 |
Reconstitution Method | Reconstitute with deionized water |
Purification | Purified from cell culture supernatant by affinity chromatography |
Conjugation | Unconjugated |
Storage | Store at -20°C for 12 months (Avoid repeated freezing and thawing) |
Stability | 12 months from date of despatch |
Predicted Protein Size | 20kDa |
Gene Name | tumor necrosis factor receptor superfamily member 17 |
Database Link | |
Background | BiTE bispecific antibody is an Engineered fusion protein constructed from two single-chain variable fragments (scFvs) of different monoclonal antibodies. One of the scFvs will be constructed from an anti-CD3 monoclonal antibody, and the other scFv fragment which linked by a linker region will be made from an anti-Tumor cell specific monoclonal antibody.The B-cell maturation protein (BCMA or BCM) is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008] |
Synonyms | BCM; BCMA; CD269 |
Reference Data |
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