CD38 Rabbit Monoclonal Antibody [Clone ID: DM28]

CAT#: TA355179

CD38 rabbit monoclonal antibody, clone DM28

Product Images

Figure 1. Expi 293 cell line transfected with irrelevant protein (left) and human CD38(right) were surface stained with Rabbit anti-CD38 monoclonal antibody 1µg/ml (clone: DM28) followed by Alexa 488-conjugated anti-rabbit IgG secondary antibody.

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  Figure 2. Flow cytometry data of serially titrated Rabbit anti-CD38 monoclonal antibody ( clone: DM28 ) on Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.

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  Figure 3. Affinity ranking of different Rabbit anti-CD38 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.

Specifications

Product Data

• Clone Name: DM28
• Applications: ELISA, FC
• Recommended Dilution: ELISA 1/5000-10000; Flow Cyt 1/100
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant human CD38 (Val43-IIe300)(TP723927) produced by using human HEK293 cells
• Formulation: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
  Preservative: 0.1% Procline 300
• Reconstitution Method: Reconstitute with deionized water
• Purification: Purified from cell culture supernatant by affinity chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C for 12 months (Avoid repeated freezing and thawing)
• Stability: 12 months from date of despatch
• Predicted Protein Size: 34kDa
• Gene Name: CD38 molecule
• Database Link:
  Entrez Gene 952 Human
  UniProt ID P28907
• Background: CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
• Synonyms: T10