alpha Synuclein (SNCA) Mouse Monoclonal Antibody [Clone ID: KM51]

CAT#: TA355218

Alpha-Synuclein Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: KM51
• Applications: IHC
• Recommended Dilution: 1:20–1:40
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to the majority of the full length alpha-synuclein molecule
• Specificity: Alpha-synuclein, also known as the non-AB component of Alzheimer’s disease amyloid precursor protein (NCAP). Does not crossreact with beta-synuclein
• Formulation: Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: synuclein alpha
• Database Link:
  Entrez Gene 6622 Human
• Background: Alpha-synuclein is a protein of 140 amino acids and a member of the synuclein family. It shares 61% sequence homology with beta-synuclein and is highly conserved between vertebrate species. It does not possess a signal sequence suggesting that it is an intracellular protein. All synucleins have an unusual organization based around the eleven residue repeating motif and an alpha-helical secondary structure resembling those found in the lipid-binding domain of exchangeable apolipoproteins, including Apo E. This homology suggests a direct interaction of alpha-synuclein with membranes consistent with its affinity for synaptosomes.
  The function of alpha-synuclein may be to carry a target protein to the inner membrane of nerve terminals or to the outer surface of synaptic vesicles. Western Blot analyses of highly purified Lewy bodies from Lewy body dementia brain material has shown full-length, partially truncated and insoluble aggregates of alpha-synuclein.
  Alpha-synuclein may be implicated in the formation of Lewy bodies and the selective degeneration of neurons in sporadic Parkinson's disease and Lewy body dementia.
• Synonyms: alpha-synuclein; MGC110988; NACP; OTTHUMP00000161559; OTTHUMP00000161561; PARK1; PARK4; PD1