BOB1 (POU2AF1) Mouse Monoclonal Antibody [Clone ID: TG14]

CAT#: TA355222

B Cell Specific Octamer Binding Protein-1 (BOB-1) Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: TG14
• Applications: IHC
• Recommended Dilution: 1:20
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: A prokaryotic recombinant protein corresponding to 116 amino acids of the C-terminal region of the
• Specificity: Human B cell specific octamer binding protein-1 (BOB-1).
• Formulation: Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: POU class 2 associating factor 1
• Database Link:
  Entrez Gene 5450 Human
• Background: B cell specific octamer binding protein-1 (BOB-1), also known as OBF-1 and OCA-B, is a lymphocyte specific transcriptional coactivator protein. It interacts with OCT1 and OCT2 transcription factors and contributes to the transcriptional activity of octamer motifs. BOB-1 is used alongside OCT2 to differentiate between classic Hodgkin's lymphoma (both down regulated) and nodular lymphocyte predominant Hodgkin's lymphoma.
  BOB-1 has been reported to be detectable in all B cell populations found in reactive lymphoid tissues. The strongest expression being found in germinal center B cells and plasma cells.
  The expression of BOB-1 in B cell tumors has been reported to be variable. Used alongside OCT2 to differentiate between classic Hodgkin's lymphoma (both down regulated) and nodular lymphocyte predominant Hodgkin's lymphoma.
  
• Synonyms: BOB-1; BOB1; OBF-1; OBF1; OCA-B; OCAB