BCL2 Mouse Monoclonal Antibody [Clone ID: BCL-2/100/D5]

CAT#: TA355223

Bcl-2 Oncoprotein Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: BCL-2/100/D5
• Applications: IHC
• Recommended Dilution: 1:100
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: B cell specific octamer binding protein-1 molecule
• Specificity: Human bcl-2 oncoprotein
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: B-cell CLL/lymphoma 2
• Database Link:
  Entrez Gene 596 Human
• Background: Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2 is an integral inner mitochondrial membrane protein of 25 kD and has a wide tissue distribution. It is considered to act as an inhibitor of apoptosis. For this reason, bcl-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway.
  In 90% of follicular lymphomas a translocation occurs which juxtaposes the bcl-2 gene at 18q21, to an immunoglobulin gene. This t(14;18) translocation can deregulate gene expression and bcl-2 over-expression can be demonstrated immunohistochemically in the vast majority of follicular lymphomas.
• Synonyms: Bcl-2; OTTHUMP00000163680