IL3RA Mouse Monoclonal Antibody [Clone ID: BR4MS]

CAT#: TA355262

CD123 Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: BR4MS
• Applications: IHC
• Recommended Dilution: 1:100
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to 101 amino acids of the external domain of the human CD123 molecule.
• Specificity: Human CD123
• Formulation: Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: interleukin 3 receptor subunit alpha
• Database Link:
  Entrez Gene 3563 Human
• Background: The CD123 antigen is also known as the alpha subunit of the human interleukin-3 receptor. It is a type I transmembrane glycoprotein and is a member of the cytokine receptor superfamily. CD123 forms a heterodimer with CD131 (the beta subunit of the interleukin-3 receptor) to form the interleukin-3 receptor, where the cytokine specificity is provided by the alpha subunit and the signal transduction function is provided by the beta subunit. The interleukin-3 receptor is reported to be expressed on monocytes, neutrophils, basophils, eosinophils, megakaryocytes, erythroid precursors, mast cells, macrophages and a subpopulation of B cells, where it mediates proliferation and differentiation of these cells. Outside the hematopoietic system CD123 is reported to be expressed in Leydig cells of the testis, some endothelial cells, and cells of the placenta and brain.
• Synonyms: CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY; IL3RX; IL3RY; MGC34174