Thrombomodulin (THBD) Mouse Monoclonal Antibody [Clone ID: 15C8]

CAT#: TA355263

CD141 (Thrombomodulin) Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: 15C8
• Applications: IHC
• Recommended Dilution: 1:100
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to the epidermal growth factor homology domain of the human CD141 molecule
• Specificity: Human thrombomodulin, also known as fetomodulin, endothelial anticoagulant protein, glycoprotein P112 and CD141
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: thrombomodulin
• Database Link:
  Entrez Gene 7056 Human
• Background: Thrombomodulin is a transmembrane glycoprotein of 75 kD which can accelerate the activation of protein C. Activated protein C functions as an anticoagulant by combining with protein S to inactivate factors Va and VIIIa of the blood coagulation pathway and by binding thrombin. Several factors regulate thrombomodulin expression. Downregulation of thrombomodulin may be induced by the cytokine interleukin-1, tumor necrosis factor and endotoxin. Agents which increase cyclic AMP such as forskolin may upregulate thrombomodulin activity in endothelial cells. Thrombomodulin has been identified within a number of normal tissues. These include the lining cells of arteries, veins, capillaries and the lymphatics as well as mesothelial cells, meningeal lining cells, synovial cells, syncytiotrophoblasts, megakaryocytes and platelets.
• Synonyms: AHUS6; CD141; fetomodulin; THRM; thrombomodulin; TM