EGFR Mouse Monoclonal Antibody [Clone ID: EGFR.113]

CAT#: TA355292

Epidermal Growth Factor Receptor Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: EGFR.113
• Applications: IHC
• Recommended Dilution: 1:20
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Prokaryotic fusion protein corresponding to the external domain of the epidermal growth factor receptor molecule
• Specificity: External domain of the human epidermal growth factor receptor
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: epidermal growth factor receptor
• Database Link:
  Entrez Gene 1956 Human
• Background: Epidermal growth factor receptor (EGFR) is a transmembrane protein receptor of 170 kD with tyrosine kinase activity. Increased levels of EGFR are reported to be linked with malignant transformation of squamous cells, for example, in squamous cell carcinoma of the lung, head, neck, skin, cervix and esophagus. EGFR may also play a role in the development and progression of hepatocellular carcinomas where recurrence rates are higher in EGFR-positive cases. This correlation has similarly been reported in colorectal cancers where EGFR, produced by tumor cells, plays an important role in the invasiveness and proliferation of colorectal cancers. The majority of published studies of EGFR expression in human breast cancer has similarly shown an association with EGFR expression where it is inversely related to estrogen receptor status.
• Synonyms: ERBB; ERBB1; HER1; mENA; PIG61