Geminin (GMNN) Mouse Monoclonal Antibody [Clone ID: EM6]

CAT#: TA355300

Geminin Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: EM6
• Applications: IHC
• Recommended Dilution: 1:40
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: A prokaryotic recombinant protein containing amino acids 5–209 of the mature protein
• Specificity: Human Geminin
• Formulation: Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: geminin, DNA replication inhibitor
• Database Link:
  Entrez Gene 51053 Human
• Background: Geminin is a protein of 209 amino acids thought to be involved in the control of DNA replication via the interaction with Cdt1. Geminin is not found in the G1 phase of the cell cycle, but is first expressed in the G1 to S transition phase, with expression levels rising through the rest of the cell cycle and levels reaching a maximum during mitosis. It has been proposed that geminin may be a tumor suppressor protein. Geminin is reported to be expressed in proliferating lymphocytes and epithelial cells, for example, germinal centers in tonsil as well as in colon, spermatocytes, seminiferous tubules of the testes, within the basal layers of the squamous epithelium of the skin and breast. Geminin is reported to be upregulated in cancers such as non-Hodgkin's lymphoma, B cell lymphoma, breast carcinoma and colon carcinoma.
• Synonyms: Gem; geminin; RP3-369A17.3