Granzyme B (GZMB) Mouse Monoclonal Antibody [Clone ID: 11F1]

CAT#: TA355302

Granzyme B Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: 11F1
• Applications: IHC
• Recommended Dilution: 1:80
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant prokaryotic fusion protein corresponding to the N-terminus of the mature granzyme B molecule
• Specificity: Human granzyme B
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: granzyme B
• Database Link:
  Entrez Gene 3002 Human
• Background: Granzymes are neutral serine proteases which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. These CTL and NK cells are heavily involved in the elimination of neoplastic and virally infected cells. Secretory granules containing perforin and granzymes are instrumental in undertaking cytolytic activity. Granzyme B is understood to enter a target cell through a perforin pore-formed channel to induce DNA fragmentation and apoptosis. Granzyme B has also been described in neoplastic CTL and NK cells.
• Synonyms: C11; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA-1; CTLA1; CTSGL1; Fragmentin-2; Granzyme-2; GRB; HLP; SECT