MSH6 Mouse Monoclonal Antibody [Clone ID: PU29]

CAT#: TA355317

MISMATCH (MSH6) Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: PU29
• Applications: IHC
• Recommended Dilution: 1:100
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to a 359 amino acid portion of the MSH6 human molecule
• Specificity: Human mismatch repair protein 6
• Formulation: Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: mutS homolog 6
• Database Link:
  Entrez Gene 2956 Human
• Background: MSH6 is a 160 kD protein which is involved in DNA mismatch repair (MMR) and recombination pathways, when heterodimerized with MSH2. Defects in mismatch repair systems can cause mutations and can cause DNA microsatellite sequences to become unstable. Immunohistochemical studies have reported that MSH6 is strongly expressed in the nucleus of cells in normal colonic epithelium, especially in crypts. Expression is also found in lymphocytes. Studies have also shown that MSH6 is expressed in gastric carcinomas and endometrial carcinomas. However, sometimes expression can be lost in some endometrial carcinomas and colonic carcinomas with microsatellite instability.
• Synonyms: GTBP; GTMBP; HNPCC5; HSAP; p160