Oct4 (POU5F1) Mouse Monoclonal Antibody [Clone ID: N1NK]

CAT#: TA355327

Oct-3/4 Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: N1NK
• Applications: IHC
• Recommended Dilution: 1:100
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to 147 amino acids of the N-terminus of the human Oct-3/4 molecule
• Specificity: Human Oct-3/4
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: POU class 5 homeobox 1
• Database Link:
  Entrez Gene 5460 Human
• Background: Oct-3/4 is a member of the POU homeodomain family of transcription factors, which is expressed by embryonic stem cells and germ cells. A critical amount of Oct-3/4 is required to maintain stem cell self replication. Down regulation of Oct-3/4 levels are associated with loss of pluripotency. Oct-3/4 has been proposed as a useful marker for germ cell tumors which exhibit features of pluripotentiality, including seminoma/dysgerminoma/germinoma and embryonal carcinoma, and establishing a germ cell origin for some metastatic tumors of uncertain primary origin.
• Synonyms: MGC22487; Oct-3; Oct-4; OCT3; OCT4; OTF3; OTF4