p21 (CDKN1A) Mouse Monoclonal Antibody [Clone ID: 4D10]

CAT#: TA355328

p21 (WAF1 Protein) Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: 4D10
• Applications: IHC
• Recommended Dilution: 1:20 - 1:40
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant fusion protein corresponding to the full length WAF1 molecule
• Specificity: Human WAF1 protein. (Also referred to as p21, Cip1 and sdi1 protein)
• Formulation: Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: cyclin-dependent kinase inhibitor 1A
• Database Link:
  Entrez Gene 1026 Human
• Background: The gene encoding WAF1, also termed p21, is transcriptionally regulated by the suppressor protein, p53. Overexpression of WAF1 is growth suppressive, possibly by inhibiting the activity of cyclin/CDK complexes. One consequence of WAF1 binding to cyclin/CDK complexes is the inhibition of Rb protein phosphorylation. Induction of WAF1 expression requires wild type p53 activity in cells undergoing p53 dependent G1 arrest or apoptosis. Mutation of the p53 gene is a common event in human cancer and results in the failure to produce WAF1. The effect of this may lead to uncontrolled cell proliferation.
• Synonyms: CAP20; CDKN1; CIP1; MDA-6; MDA6; OTTHUMP00000016298; P21; p21CIP1; p21Cip1/Waf1; PIC1; SDI1; WAF1