p57 Kip2 (CDKN1C) Mouse Monoclonal Antibody [Clone ID: 25B2]

CAT#: TA355329

p57 Protein (Kip2) Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: 25B2
• Applications: IHC
• Recommended Dilution: 1:50
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant antigen corresponding to a 116 amino acid region of the N-terminus of the p57 protein
• Specificity: Human p57 protein, also known as Kip2 protein
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: cyclin-dependent kinase inhibitor 1C
• Database Link:
  Entrez Gene 1028 Human
• Background: Cyclin-dependent kinases are positive regulators of cell proliferation. p57 protein acts as a tumor suppressor to counter this. It is closely related to other CDKIs such as p21 protein (CIP1) and p27 protein (Kip1) as they share a common structural N-terminal domain for binding to CDK/cyclin complexes and inhibiting their kinase activity. Human p57 protein is found on chromosome 11p15.5, a region which is reported to be a common site for loss of heterozygosity in certain sarcomas, Wilms' tumors and tumors associated with the Beckwith-Wiedemann syndrome. There is increasing interest in p57 as a marker in gestational disease. Gestational trophoblastic disease refers to a spectrum of proliferative disorders of the placental trophoblast, with a wide range of histologic appearances and clinical behaviors. Recent developments in changes in the criteria for histologic diagnosis of these lesions due to earlier clinical diagnosis have been reviewed Hui P et al., Advantages in Anatomical Pathology. 12(3): 116-125 (2005) and the ability to make more accurate diagnoses due to the introduction of newer antibodies such as p57 is discussed.
• Synonyms: BWCR; BWS; KIP2; p57; p57KIP2; WBS