PSMA (FOLH1) Mouse Monoclonal Antibody [Clone ID: 1D6]

CAT#: TA355343

Prostate Specific Membrane Antigen Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: 1D6
• Applications: IHC
• Recommended Dilution: 1:50
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Expressed from a 108 amino acid region of the extra cellular domain (301-409aa) of the human PSMA molecule
• Specificity: Human prostate specific membrane antigen
• Formulation: Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: folate hydrolase (prostate-specific membrane antigen) 1
• Database Link:
  Entrez Gene 2346 Human
• Background: The prostate specific membrane antigen (PSMA) is expressed as a 750 amino acid glycoprotein but may also be found as PSM, a form of the protein missing the first 57 amino acids. PSMA has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase. Reports suggest that PSMA expression may correlate with tumor burden and serve as an indicator of metastatic involvement. The cellular localization of PSMA contrasts with that of prostate specific antigen (PSA) and prostatic acid phosphatase (PAP) that are secreted proteins.
• Synonyms: FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA