Tyrosine Hydroxylase (TH) Mouse Monoclonal Antibody [Clone ID: 1B5]

CAT#: TA355355

Tyrosine Hydroxylase Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: 1B5
• Applications: IHC
• Recommended Dilution: 1:40
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to a portion of the carboxyl terminal end of the mouse tyrosine hydroxylase molecule.
• Specificity: Human tyrosine hydroxylase. Also reacts with mouse and rat tyrosine hydroxylase
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: tyrosine hydroxylase
• Database Link:
  Entrez Gene 7054 Human
• Background: Tyrosine hydroxylase is the first enzyme in catecholamine (CA) biosynthesis and catalyzes the conversion of L-tyrosine to L-DOPA. Tyrosine hydroxylase is reported to be expressed in all CA neurons. Despite the abundant data about the distribution of catecholaminergic neurons in a wide variety of species, data on their distribution in the human brain is less comprehensive. However, one such study has reported that tyrosine hydroxylase products in the substantia nigra were restricted to neural bodies, axons and dendrites. These in turn were restricted to the third decade of life and their number increased in this location with age. This finding may be related to ageing of melanin-pigmented neurons.
• Synonyms: DYT5b; DYT14; TYH