Nr1h3 Rabbit Polyclonal Antibody

CAT#: TA355559

Nr1h3 Antibody - C-terminal region

Product Images

WB Suggested Anti-Nr1h3 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Heart

Specifications

Product Data

• Applications: WB
• Reactivities: Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
  Homology: Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 50kDa
• Gene Name: nuclear receptor subfamily 1, group H, member 3
• Database Link:
  NP_038867
  Entrez Gene 22259 Mouse
  UniProt ID Q9Z0Y9
• Background: Nr1h3 is an orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Nr1h3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
• Synonyms: LXR-a; LXRA; OTTHUMP00000198038; RLD-1