Nkx3-1 Rabbit Polyclonal Antibody

CAT#: TA355874

Nkx3-1 Antibody - middle region

Product Images

Host: Rabbit Target Name: Nkx3-1 Sample Type: Mouse Lung lysates Antibody Dilution: 1.0ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Mouse Nkx3-1
• Specificity: Expected reactivity: Mouse
  Homology: Mouse: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 27kDa
• Gene Name: NK-3 transcription factor, locus 1 (Drosophila)
• Database Link:
  NP_035051
  Entrez Gene 18095 Mouse
  UniProt ID P97436
• Background: Nkx3-1 is a transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. It plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Nkx3-1 acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells and plays a role in the formation of minor salivary glands (particularly palatine and lingual glands). It is essential for appropriate differentiation and secretory function of the bulbourethral gland.