Fbxw7 Rabbit Polyclonal Antibody

CAT#: TA355887

Fbxw7 Antibody - middle region

Product Images

WB Suggested Anti-Fbxw7 Antibody Titration: 0.2-1 ug/ml Positive Control: Mouse Lung

• 

  Mouse Brain

Specifications

Product Data

• Applications: IHC, WB
• Reactivities: Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse Fbxw7
• Specificity: Expected reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
  Homology: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 93%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 93%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 70kDa
• Gene Name: F-box and WD-40 domain protein 7
• Database Link:
  NP_536353
  Entrez Gene 50754 Mouse
  UniProt ID Q8VBV4
• Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
• Synonyms: AGO; CDC4; DKFZp686F23254; FBW6; FBW7; FBX30; FBXO30; FBXW6; FLJ11071; FLJ16457; hAgo; hCdc4; SEL-10; SEL10