Runx1 Rabbit Polyclonal Antibody

CAT#: TA355930

Runx1 Antibody - N-terminal region

Product Images

Host: Rabbit Target Name: Runx1 Sample Type: Mouse Skeletal Muscle lysates Antibody Dilution: 1.0ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of MOUSE Runx1
• Specificity: Expected reactivity: Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
  Homology: Cow: 79%; Dog: 79%; Guinea Pig: 79%; Human: 79%; Mouse: 100%; Rabbit: 79%; Rat: 93%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 42kDa
• Gene Name: runt related transcription factor 1
• Database Link:
  NP_033951
  Entrez Gene 12394 Mouse
  UniProt ID Q03347-2
• Background: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Runx1 is essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Runx1 acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. It inhibits KAT6B-dependent transcriptional activation .
• Synonyms: AML1; AMLCR1; CBF-alpha-2; CBFA2; EVI-1; OTTHUMP00000108697; PEBP2A2; PEBP2aB