DAB2 Rabbit Polyclonal Antibody

CAT#: TA356167

DAB2 Antibody - N-terminal region

Product Images

Host: Rabbit Target Name: DAB2 Sample Type: PANC1 Whole Cell lysates Antibody Dilution: 1.0ug/ml

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  Host: Mouse Target Name: DAB2 Sample Tissue: Mouse Spleen Antibody Dilution: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human DAB2
• Specificity: Expected reactivity: Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
  Homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 60kDa
• Gene Name: DAB2, clathrin adaptor protein
• Database Link:
  Entrez Gene 1601 Human
  UniProt ID P98082-2
• Background: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Synonyms: DOC-2; DOC2; FLJ26626