LIN7C Rabbit Polyclonal Antibody

CAT#: TA356244

LIN7C Antibody - N-terminal region

Product Images

WB Suggested Anti-LIN7°C Antibody Titration: 1 ug/ml Positive Control: HepG2 cell lysate

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  Immunohistochemistry with Human Colon lysate tissue at an antibody concentration of 5.0ug/ml using anti-LIN7°C antibody (TA356244)

Specifications

Product Data

• Applications: IHC, WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LIN7C
• Specificity: Expected reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
  Homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 22kDa
• Gene Name: lin-7 homolog C, crumbs cell polarity complex component
• Database Link:
  NP_060832
  Entrez Gene 55327 Human
  UniProt ID Q9NUP9
• Background: LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
• Synonyms: FLJ11215; LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3

Reference Data

• Protein Families: Druggable Genome