ATP6V0C Rabbit Polyclonal Antibody

CAT#: TA356453

ATP6V0C Antibody - middle region

Product Images

Host: Rabbit Target Name: ATP6V0C Sample Type: Human Lung Antibody Dilution: 1.0 ug/ml

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  Host: Rabbit Target Name: ATP6V0C Sample Tissue: Human RPMI 8226 Whole Cell Antibody Dilution: 1ug/ml

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  Host: Rabbit Target Name: ATP6V0C Sample Tissue: Human COLO205 Whole Cell Antibody Dilution: 3ug/ml

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  Host: Rabbit Target: ATP6V0C Positive control (+): RPMI-8226 (N12) Negative control (-): U937 (N31) Antibody concentration: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATP6V0C
• Specificity: Expected reactivity: Cow, Dog, Horse, Human, Pig, Rabbit, Rat, Sheep
  Homology: Cow: 86%; Dog: 86%; Horse: 93%; Human: 100%; Pig: 79%; Rabbit: 86%; Rat: 90%; Sheep: 86%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 16kDa
• Gene Name: ATPase H+ transporting V0 subunit c
• Database Link:
  NP_001685
  Entrez Gene 527 Human
  UniProt ID P27449
• Background: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the V0 domain. This gene had the previous symbols of ATP6C and ATP6L.
• Synonyms: ATP6C; ATP6L; ATPL; VATL; Vma3

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Epithelial cell signaling in Helicobacter pylori infection, Lysosome, Metabolic pathways, Oxidative phosphorylation, Vibrio cholerae infection