LTB Rabbit Polyclonal Antibody

CAT#: TA356485

LTB Antibody - N-terminal region

Product Images

WB Suggested Anti-LTB Antibody Titration: 0.2-1 ug/ml Positive Control: Human Thymus

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LTB
• Specificity: Expected reactivity: Guinea Pig, Horse, Human, Rabbit
  Homology: Guinea Pig: 79%; Horse: 91%; Human: 100%; Rabbit: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 25kDa
• Gene Name: lymphotoxin beta
• Database Link:
  NP_002332
  Entrez Gene 4050 Human
  UniProt ID Q06643
• Background: Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Synonyms: LT-beta; lymphotoxin-beta; p33; TNF-C; TNFC; TNFSF3

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction