PCDHGC3 Rabbit Polyclonal Antibody

CAT#: TA356499

PCDHGC3 Antibody - C-terminal region

Product Images

WB Suggested Anti-PCDHGC3 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: 721_B cell lysateThere is BioGPS gene expression data showing that PCDHGC3 is expressed in 721_B

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  Host: Rabbit Target Name: CHAD Sample Type: Human Adult Placenta Antibody Dilution: 1.0ug/ml

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  Host: Rabbit Target Name: PCDHGC3 Sample Type: 293T Antibody Dilution: 1.0ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PCDHGC3
• Specificity: Expected reactivity: Cow, Guinea Pig, Horse, Human, Mouse, Rat
  Homology: Cow: 92%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 98kDa
• Gene Name: protocadherin gamma subfamily C, 3
• Database Link:
  NP_002579
  Entrez Gene 5098 Human
  UniProt ID Q9UN70
• Background: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. PCDHGC3 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
• Synonyms: PC-43; PC43; PCDH-GAMMA-C3; PCDH2; Protocadherin-2; Protocadherin-43

Reference Data

• Protein Families: Transmembrane