Tapasin (TAPBP) Rabbit Polyclonal Antibody

CAT#: TA356533

TAPBP Antibody - C-terminal region

Product Images

WB Suggested Anti-TAPBP Antibody Titration: 0.5ug/ml Positive Control: HepG2 cell lysate

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  WB Suggested Anti-TAPBP antibody Titration: 1 ug/mL Sample Type: Human liver

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  Human Skin

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  Rabbit Anti-TAPBP Antibody Catalog Number: TA356533 Formalin Fixed Paraffin Embedded Tissue: Human Adult liver Observed Staining: Cytoplasmic Primary Antibody Concentration: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy2/3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 – 2.0 sec Protocol located in Reviews and Data.

Specifications

Product Data

• Applications: IHC, WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TAPBP
• Specificity: Expected reactivity: Cow, Human, Pig, Sheep
  Homology: Cow: 86%; Human: 100%; Pig: 86%; Sheep: 86%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 46kDa
• Gene Name: TAP binding protein (tapasin)
• Database Link:
  NP_003181
  Entrez Gene 6892 Human
  UniProt ID O15533
• Background: TAPBP is a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum.This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
• Synonyms: NGS17; TAPA; TPN; TPSN

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Antigen processing and presentation