Endostatin (COL18A1) Rabbit Polyclonal Antibody

CAT#: TA356579

COL18A1 Antibody - Middle region

Product Images

Host: Rabbit Target Name: COIA1 Sample Type: MCF7 Whole Cell Antibody Dilution: 1.0ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen for Anti-COL18A1 antibody is: synthetic peptide directed towards the Middle region of Human COIA1
• Specificity: Expected reactivity: Cow, Horse, Human, Pig, Rabbit
  Homology: Cow: 92%; Horse: 83%; Human: 100%; Pig: 83%; Rabbit: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 147 kDa
• Gene Name: collagen type XVIII alpha 1 chain
• Database Link:
  Entrez Gene 80781 Human
  UniProt ID P39060-2
• Background: This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.
• Synonyms: FLJ27325; FLJ34914; KNO; KNO1; MGC74745