SIGIRR Rabbit Polyclonal Antibody

CAT#: TA356821

SIGIRR Antibody - C-terminal region

Product Images

Host: Rabbit Target Name: SIGIRR Sample Type: Human Adult Placenta Antibody Dilution: 1.0ug/ml

• 

  Liver

Specifications

Product Data

• Applications: IHC, WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SIGIRR
• Specificity: Expected reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rat, Zebrafish
  Homology: Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 86%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 25kDa
• Gene Name: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
• Database Link:
  Entrez Gene 59307 Human
  UniProt ID Q6IA17
• Background: SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.
• Synonyms: MGC110992; TIR8