Cathepsin E (CTSE) Rabbit Polyclonal Antibody

CAT#: TA357668

CTSE Antibody - N-terminal region

Product Images

WB Suggested Anti-CTSE Antibody Titration: 1.0 ug/ml Positive Control: NCI-H226 Whole Cell

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Horse, Human
  Homology: Horse: 79%; Human: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 40kDa
• Gene Name: cathepsin E
• Database Link:
  NP_683865
  Entrez Gene 1510 Human
  UniProt ID P14091
• Background: The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.
• Synonyms: CATE

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Lysosome