OGG1 Rabbit Polyclonal Antibody

CAT#: TA357818

OGG1 Antibody - C-terminal region

Product Images

WB Suggested Anti-OGG1 Antibody Titration: 1.0 ug/ml Positive Control: ACHN Whole Cell

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Directed against isoforms 2D, 1A, 1B, 2E.
  
  Expected reactivity: Cow, Dog, Horse, Human, Mouse, Pig, Rat
  Homology: Cow: 93%; Dog: 100%; Horse: 86%; Human: 100%; Mouse: 86%; Pig: 92%; Rat: 79%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 38kDa
• Gene Name: 8-oxoguanine DNA glycosylase
• Database Link:
  NP_058438
  Entrez Gene 4968 Human
  UniProt ID O15527
• Background: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization.
• Synonyms: HMMH; HOGG1; MMH; MUTM; OGH1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Base excision repair