AKR1C3 Rabbit Polyclonal Antibody

CAT#: TA357873

AKR1C3 Antibody - N-terminal region

Product Images

WB Suggested Anti-AKR1C3 Antibody Titration: 1.0 ug/ml Positive Control: COLO205 Whole CellAKR1C3 is supported by BioGPS gene expression data to be expressed in COLO205

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  Rabbit Anti-AKR1C3 Antibody Catalog Number: TA357873 Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Cytoplasmic Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec

Specifications

Product Data

• Applications: IHC, WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Cow, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat
  Homology: Cow: 85%; Guinea Pig: 85%; Human: 100%; Mouse: 77%; Pig: 92%; Rabbit: 86%; Rat: 85%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 36kDa
• Gene Name: aldo-keto reductase family 1, member C3
• Database Link:
  NP_003730
  Entrez Gene 8644 Human
  UniProt ID P42330
• Background: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
• Synonyms: DD-3; DD3; DDH1; DDX; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; KIAA0119; PGFS

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arachidonic acid metabolism, Metabolism of xenobiotics by cytochrome P450