BRCC36 (BRCC3) Rabbit Polyclonal Antibody

CAT#: TA358024

BRCC3 Antibody - C-terminal region

Product Images

WB Suggested Anti-BRCC3 Antibody Titration: 1.0 ug/ml Positive Control: Fetal Heart

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  Host: Rabbit Target Name: BRCC3 Sample Type: Human Hela Antibody Dilution: 1.0ug/mlBRCC3 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells

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  Sample Type: MCF7 Primary Antibody Dilution: 4 ug/ml Secondary Antibody: Anti-rabbit Alexa 546 Secondary Antibody Dilution: 2 ug/ml Gene Name: BRCC3

Specifications

Product Data

• Applications: IF, WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Cow, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
  Homology: Cow: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 93%; Rat: 86%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 35kDa
• Gene Name: BRCA1/BRCA2-containing complex subunit 3
• Database Link:
  NP_077308
  Entrez Gene 79184 Human
  UniProt ID P46736
• Background: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy.
• Synonyms: BRCC36; c6.1A; CXorf53

Reference Data

• Protein Families: Druggable Genome, Protease