PDE5A Rabbit Polyclonal Antibody

CAT#: TA358387

PDE5A Antibody - C-terminal region

Product Images

WB Suggested Anti-PDE5A Antibody Titration: 1.0 ug/ml Positive Control: Placenta

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  Sample Type: Human placental tissue Primary Antibody Dilution: 1:100 Secondary Antibody: Goat anti rabbit-HRP Secondary Antibody Dilution: 1:10,000 Color/Signal Descriptions: Brown: PDE5A Purple: Haemotoxylin Gene Name: PDE5A Submitted by: Dr. Hiten D. Mistry and Anna Czajka, King's College London; Lesia Kurlak, University of Nottingham

Specifications

Product Data

• Applications: IHC, WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
  Homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 82%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 93kDa
• Gene Name: phosphodiesterase 5A
• Database Link:
  NP_246273
  Entrez Gene 8654 Human
  UniProt ID O76074
• Background: This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.
• Synonyms: CGB-PDE; CN5A; PDE5; PDE5A1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Progesterone-mediated oocyte maturation, Purine metabolism