Folylpolyglutamate synthase (FPGS) Rabbit Polyclonal Antibody

CAT#: TA358432

FPGS Antibody - middle region

Product Images

WB Suggested Anti-FPGS Antibody Titration: 1.0 ug/ml Positive Control: Fetal Heart

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  Rabbit Anti-FPGS Antibody Catalog Number: TA358432 Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Cytoplasmic in mitochondria Primary Antibody Concentration: N/A Other Working Concentrations: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec

Specifications

Product Data

• Applications: IHC, WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Human
  Homology: Human: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 59kDa
• Gene Name: folylpolyglutamate synthase
• Database Link:
  NP_001018088
  Entrez Gene 2356 Human
  UniProt ID Q5JU19
• Background: This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.
• Synonyms: FPGS

Reference Data

• Protein Pathways: Folate biosynthesis, Metabolic pathways