FUT3 Rabbit Polyclonal Antibody

CAT#: TA358578

FUT3 Antibody - C-terminal region

Product Images

WB Suggested Anti-FUT3 Antibody Titration: 1.0 ug/ml Positive Control: Fetal Kidney

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Human, Pig
  Homology: Human: 100%; Pig: 77%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 42kDa
• Gene Name: fucosyltransferase 3 (Lewis blood group)
• Database Link:
  NP_000140
  Entrez Gene 2525 Human
  UniProt ID P21217
• Background: The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
• Synonyms: alpha-(1,3/1,4)-fucosyltransferase; CD174; FT3B; FucT-III; LE; Les; MGC131739

Reference Data

• Protein Pathways: Glycosphingolipid biosynthesis - lacto and neolacto series, Metabolic pathways