TPM1 Rabbit Polyclonal Antibody

CAT#: TA358720

TPM1 Antibody - N-terminal region

Product Images

Host: Rabbit Target Name: TPM1 Sample Type: 721_B Whole Cell lysates Antibody Dilution: 1.0ug/ml

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  WB Suggested Anti-TPM1 antibody Titration: 1 ug/mL Sample Type: Human NCI-H226

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  Host: Mouse Target Name: TPM1 Sample Tissue: Mouse Kidney Antibody Dilution: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human TPM1
• Specificity: Expected reactivity: Cow, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
  Homology: Cow: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 31kDa
• Gene Name: tropomyosin 1 (alpha)
• Database Link:
  XP_006720731
  Entrez Gene 7168 Human
  UniProt ID P09493
• Background: This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.
• Synonyms: Alpha-tropomyosin; C15orf13; CMD1Y; CMH3; HTM-alpha; TMSA; Tropomyosin-1