DMGDH Rabbit Polyclonal Antibody

CAT#: TA358745

DMGDH Antibody - C-terminal region

Product Images

WB Suggested Anti-DMGDH Antibody Titration: 1.0 ug/ml Positive Control: Fetal Liver

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Horse, Human, Pig, Rat
  Homology: Horse: 92%; Human: 100%; Pig: 100%; Rat: 93%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 91kDa
• Gene Name: dimethylglycine dehydrogenase
• Database Link:
  NP_037523
  Entrez Gene 29958 Human
  UniProt ID Q9UI17
• Background: This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum.
• Synonyms: DMGDHD; ME2GLYDH

Reference Data

• Protein Pathways: Glycine, serine and threonine metabolism, Metabolic pathways