KDM5B Rabbit Polyclonal Antibody

CAT#: TA359227

KDM5B Antibody - C-terminal region

Product Images

Host: Rabbit Target Name: KDM5B Sample Type: HepG2 Whole Cell lysates Antibody Dilution: 1.0ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human KDM5B
• Specificity: Expected reactivity: Human
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 169kDa
• Gene Name: lysine demethylase 5B
• Database Link:
  NP_006609
  Entrez Gene 10765 Human
  UniProt ID Q9UGL1
• Background: KDM5B is a histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.
• Synonyms: CT31; FLJ10538; FLJ12459; FLJ12491; FLJ16281; FLJ23670; JARID1B; PLU-1; PLU1; PUT1; RBBP2H1; RBBP2H1A; RBP2-H1; RBP2-like