ZRANB3 Rabbit Polyclonal Antibody

CAT#: TA359280

ZRANB3 Antibody - C-terminal region

Product Images

Host: Rabbit Target Name: ZRANB3 Sample Tissue: Human MCF7 Whole Cell Antibody Dilution: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ZRANB3
• Specificity: Expected reactivity: Cow, Dog, Horse, Human, Pig
  Homology: Cow: 93%; Dog: 83%; Horse: 88%; Human: 100%; Pig: 93%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 118kDa
• Gene Name: zinc finger RANBP2-type containing 3
• Database Link:
  Entrez Gene 84083 Human
  UniProt ID Q5FWF4-3
• Background: ZRANB3 is a DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. It is recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, it also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks. .
• Synonyms: 4933425L19Rik; DKFZP434B1727; MGC75012; MGC105033