UNC13B Rabbit Polyclonal Antibody

CAT#: TA360332

UNC13B Antibody - middle region

Product Images

Host: Rabbit Target Name: UNC13B Sample Tissue: Human COLO205 Whole Cell Antibody Dilution: 1.0ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human UNC13B
• Specificity: Expected reactivity: Human
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 181 kDa
• Gene Name: unc-13 homolog B (C. elegans)
• Database Link:
  NP_006368.3
  Entrez Gene 10497 Human
  UniProt ID O14795
• Background: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
• Synonyms: hmunc13; MGC133279; MGC133280; MUNC13; Munc13-2; unc-13-like; UNC13; Unc13h2