Casp1 Rabbit Polyclonal Antibody

CAT#: TA363740

CASP1 Antibody - middle region

Product Images

Host: Rabbit Target Name: CASP1 Sample Tissue: Mouse Small Intestine lysates Antibody Dilution: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse CASP1
• Specificity: Expected reactivity: Mouse
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 44 kDa
• Gene Name: caspase 1
• Database Link:
  NP_033937.2
  Entrez Gene 12362 Mouse
  UniProt ID P29452
• Background: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive.
• Synonyms: CASP-1; caspase-1; ICE; IL-1BC; IL1B-convertase; IL1BC; IL1BCE; p45