ProDynorphin (PDYN) Rabbit Polyclonal Antibody

CAT#: TA364061

Rabbit polyclonal anti Dynorphin A (1-13); diluted antiserum

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: This antibody has been tested and validated in ELISA against Dynorphin A (1-8). Other applications like immunohistochemistry (IHC), FACS or Western Blot may work as well. Optimal dilutions should be determined by the end user.
• Reactivities: Human, Mammalian
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-OH coupled to carrier protein.
• Formulation: This polyclonal antibody is supplied as a lyophilized powder. The powder should be rehydrated with 50ml of RIA buffer. Upon reconstitution to 50ml total volume, the solution contains 0.1M sodium phosphate buffer (pH 7.4), 0.05M NaCl, 0.1% BSA, 0.01% NaN3, and 0.1% Triton X-100. Store at 4° - 8°C. This should ensure antibody stability for approximately one month.
• Concentration: N/A
• Conjugation: Unconjugated
• Storage: Original vial: at least one year at 4° - 8°C from date of delivery. Minimize repeated thawing and freezing of the antiserum by freezing aliquots at -20°C or below.
• Gene Name: prodynorphin
• Database Link:
  Entrez Gene 5173 Human
  UniProt ID P01213
• Background: Dynorphin is a 17-amino acid opioid peptide found in the mammalian central nervous system, including hypothalamus, striatum, hippocampus, and spinal cord. It has a strong affinity for opiate receptors and it arises from the precursor protein prodynorphin, which is cleaved during processing by proprotein convertase 2 (PC2), releasing multiple active peptides like dynorphin A, dynorphin B, and α/β-neo- endorphin. Dynorphin A (1–8) is a truncated form of dynorphin A. It is an agonist at the mu-, kappa-, and delta-opioid receptors and it has the highest binding affinity for the kappa-opioid receptor. This antibody was generated by immunization of rabbits with Dynorphin A (1-8) coupled to a carrier protein.
• Synonyms: beta-neoendorphin; beta-neoendorphin-dynorphin; dynorphin; leu-enkephalin; leumorphin; MGC26418; PENKB; preprodynorphin; prodynorphin; rimorphin