ProDynorphin (PDYN) Rabbit Polyclonal Antibody

CAT#: TA364070

Rabbit polyclonal anti Dynorphin B; neat antiserum


USD 400.00

2 Weeks*

Size
    • 50 ul

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Specifications

Product Data
Applications ELISA
Recommended Dilution This antibody has been tested and validated in ELISA against Dynorphin B. Other applications like immunohistochemistry (IHC), FACS or Western Blot may work as well. Optimal dilutions should be determined by the end user.
Reactivities Human, Mammalian
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val- Thr-OH coupled to carrier protein.
Formulation Neat undiluted antiserum, lyophilized, packaged under nitrogen. Reconstitute by adding 50µl distilled water. This will give the equivalent of undiluted antiserum; does not contain any preservative.
Concentration N/A
Conjugation Unconjugated
Storage Original vial: at least one year at 4° - 8°C from date of delivery. Minimize repeated thawing and freezing of the antiserum by freezing aliquots at -20°C or below.
Gene Name prodynorphin
Background Dynorphins are a class of opioid peptides. As their precursor Proenkephalin-B is cleaved during processing, its residues 207-223 (Dynorphin A) and 226-238 (Rimorphin, Dynorphin B) are released, among others. Dynorphins contain a high proportion of basic and hydrophobic residues. They are widely distributed in the central nervous system, with highest concentrations in the hypothalamus, medulla, pons, midbrain, and spinal cord, where they are also produced. Dynorphins are stored in large dense-core vesicles characteristic of opioid peptides storage. Dynorphins exert their effects primarily through the κ-opioid receptor (KOR), a G-protein- coupled receptor. They are part of the complex molecular changes in the brain leading to cocaine addiction. Dynorphins are important in maintaining homeostasis through appetite control, circadian rhythms and the regulation of body temperature. However, Dynorphin derivatives are generally considered to be of little clinical use because of their short duration of action. This antibody was generated by immunization of rabbits with Dynorphin B coupled to a carrier protein.
Synonyms beta-neoendorphin; beta-neoendorphin-dynorphin; dynorphin; leu-enkephalin; leumorphin; MGC26418; PENKB; preprodynorphin; prodynorphin; rimorphin
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.